| 产品名称 |
PI3-kinase p85- alpha (Phospho-Tyr607) |
| 来源宿主: |
Rabbit |
| 反应种属: |
Human, Mouse, Rat |
| 克隆类型 |
Rabbit polyclonal |
| 同种型 |
IgG |
| 标记 |
Phosphorylated |
| 纯化方式 |
Affinity-chromatography |
| 形式 |
Liquid |
| 存储溶液 |
PBS (pH7.4),0.05% BSA,40% Glycerol. Preservative: 0.05% Sodium Azide. |
| 存储方式 |
Store at +4°C for short term. Store at -20°C for long term. Avoid freeze/thaw cycle. |
| 应用 |
WB, IHC, mIHC |
| 使用方法 |
WB 1:500-1:1000；IHC 1:50-1:100；mIHC 1:50-1:100 |
| 有效期 |
one year |
| 别名 |
GRB1, P85A, PI3-kinase p85-alpha subunit, PI3K, PI3K p85-alpha, Phosphatidylinositol 3-kinase regulatory alpha subunit, PtdIns-3-kinase p85-alpha; |
| 免疫原 |
A synthesized peptide derived from human PI3 Kinase p85 alpha around the phosphorylation site of Y607 |
| SwissProt |
P27986 |
| 分子量 |
Predicted band size: 84 kDa |
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Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.
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