The Mannose Receptor is a type of C-type lectin receptor primarily found on the surface of antigen-presenting cells such as macrophages, dendritic cells, and certain endothelial cells. It plays a crucial role in the immune system by recognizing and binding to mannose-rich glycoconjugates present on the surface of pathogens like bacteria, fungi, and viruses. Once bound, the receptor facilitates the internalization and degradation of these pathogens through endocytosis, thereby helping to clear infections and initiate immune responses. Additionally, it is involved in the clearance of apoptotic cell debris by recognizing and binding to mannose residues on glycoproteins released from dying cells. This receptor is also implicated in various inflammatory and immune-related diseases, making it an important target for therapeutic interventions.